| Home teams listed first |
|---|
| QUARTERFINALS |
| First Leg |
| Times EST |
| Tuesday, March 5 |
Houston (United States) vs. Santos Laguna (Mexico), 8 p.m.
| Wednesday, March 6 |
|---|
Xelaju (Guatemala) vs. Monterrey (Mexico), 8 p.m.
Tigres (Mexico) vs. Seattle (United States), 10 p.m.
| Thursday, March 7 |
|---|
Herediano (Costa Rica) vs. LA Galaxy (United States), 8 p.m.
| Second Leg |
|---|
| Times EDT |
| Tuesday, March 12 |
Monterrey (Mexico) vs. Xelaju (Guatemala), 8 p.m.
Seattle (United States) vs. Tigres (Mexico), 10 p.m.
| Wednesday, March 13 |
|---|
Santos Laguna (Mexico) vs. Houston (United States), 8 p.m.
LA Galaxy (United States) vs. Herediano (Costa Rica), 10 p.m.
