US 97 closed in both directions between Goldendale and Toppenish Wednesday afternoon because of a wildfire.
WSDOT said flames and smoke were causing hazardous driving conditions. A reopening time is unknown.
The Shinando Canyon Fire is burning on both sides of the road at the top of Satus Pass within the Yakima Indian Reservation.
Officials say 70 people have been evacuated.
The fire was said to be about more than 1250 acres, with no containment.
A Type 2 Incident Management Team was ordered to manage the fire.
One structure was destroyed but there are no homes in the area.
There is no word on what caused the fire.